/*  Stylesheet for NLM/NCBI  Journal Publishing 3.0 Preview HTML
    January 2009

    ~~~~~~~~~~~~~~
    National Center for Biotechnology Information (NCBI)
    National Library of Medicine (NLM)
    ~~~~~~~~~~~~~~
    
This work is in the public domain and may be reproduced, published or 
otherwise used without the permission of the National Library of Medicine (NLM).

We request only that the NLM is cited as the source of the work.

Although all reasonable efforts have been taken to ensure the accuracy and 
reliability of the software and data, the NLM and the U.S. Government  do 
not and cannot warrant the performance or results that may be obtained  by
using this software or data. The NLM and the U.S. Government disclaim all 
warranties, express or implied, including warranties of performance, 
merchantability or fitness for any particular purpose.

*/


/* --------------- Page setup ------------------------ */

/* page and tex</div>t defaults */

/*body { margin-left: 8%;
     margin-right: 8%;
     background-color: #f8f8f8 }*/

body {
    font-family: "Noto Sans", -apple-system, BlinkMacSystemFont, "Segoe UI", "Roboto", "Oxygen-Sans", "Ubuntu", "Cantarell", "Helvetica Neue", sans-serif;
    line-height: 1.4;
    margin: 0 auto;
    padding: 0 3em 1em 3em;
    max-width: 1400px;
/*    background-color: #f8f8f8*/
    }

h1,
h2,
h3,
h4,
h5,
h6,
.contrib,
.license,
.doi,
.kwd-group,
.abstract


div > *:first-child { margin-top:0em }

div { margin-top: 0.5em }

div.front, div.footer { }

.back, .body { font-family: serif; text-align: justify;}

div.metadata { font-family: sans-serif; 
  font-size: 90%; }
div.left { text-align: left }

div.table { display: table }
div.metadata.table { width: 100% }
div.row { display: table-row }
div.cell { display: table-cell; padding-left: 0.25em; padding-right: 0.25em }

div.metadata div.cell {
    vertical-align: top }

div.autor {
    font-size: 120%;
    font-weight: bold;
     line-height: 1;
}

div.info-journal {
    padding-top: 3em;
    font-size: 80%;
}

/*otros estilos generales, reseñas y otras situaciones*/

#cuadroPortada{
    float: right;
    max-width: 150px;
    padding: 5px;
    margin: 10px 0 5px 10px;
    /*text-align: center;*/
     background-color: #d2d2d4;


}
#imgPortada{
    position: relative;
    align-content: right;
    padding: 10px;
}


/* importado de articulo-base para tablas*/

/* Estilo para tablas */
.tabla {
    caption-side: top;
    table-layout: auto; width: 300px;
    border-collapse: collapse;
    border: 1px;
}

table, td, th {
  border: 1px solid black;
  
}

table {
  border-collapse: collapse;
  width: 100%;
}

caption {
    font-weight: bold;
    padding: 10px 0px;
}

th {
  text-align: center;
  padding: 8px;
  background: #b9b9c2;
}

td {
  text-align: left;
  padding: 8px;
}
/*fin de importado articulo base para tablas*/



/*div.two-column div.cell {
    width: 50% }*/

div.one-column div.cell.spanning { width: 100% }

div.metadata-group { margin-top: 0.5em;
  font-size: 80% }

div.metadata-group > p, div.metadata-group > div { margin-top: 0.5em }

div.metadata-area * { margin: 0em }

div.metadata-chunk { margin-left: 1em }

div.branding { text-align: center;
font-size: 70%}
div.subject {
   font-size: 1em;
    font-weight: bold;
   text-align: right;
   color: #1a6600;
   
}

div.document-title-notes {
   text-align: center;
   width: 60%;
   margin-left: auto;
   margin-right: auto
   }

div.footnote { font-size: 90% }

/* rules */
hr.part-rule {
    border: thin solid black;
    width: 70%;
    margin-top: 2em;
    margin-bottom: 2em;
    }

hr.section-rule {
    border: thin solid black;
    width: 70%;
    margin-top: 3em;
    margin-bottom: 2em;
    }

/* superior numbers that are cross-references */
.xref {
    color: red;
    }
    
/* generated text */     
.generated { color: black;
font-weight: bold;}

.warning, tex-math {
    font-size:80%; font-family: sans-serif }

.warning {
    color: red }

.tex-math { color: green }

.data {
    color: black;
    }

.formula {
    font-family: sans-serif;
    font-size: 90% }
    
/* --------------- Titling levels -------------------- */


h1, h2, h3, h4, h5, h6 {
   display: block;
   margin-top: 0em;
   margin-bottom: 0.5em;
   font-family: helvetica, sans-serif;
   font-weight: bold;
   color: #6d220c;
  }
/* titling level 1: document title */
.document-title {
   text-align: left;
   line-height: 1.2;
   font-size: 125%;
   font-weight: bold;
   color: #6d220c;
   }
.document-subtitle {
   text-align: left;
   line-height: 1;
   font-size: 115%;
   font-weight: bold;
   color: #6d220c;
   padding-bottom: 1em
   }
.document-title-trans {
   text-align: left;
   font-size: 90%;
   font-weight: bold;
   color: #6d220c;
   mar
   }
   
 
/* callout titles appear in a left column (table cell)
   opposite what they head */
.callout-title { text-align: right;
  margin-top: 0.5em;
  margin-right: 1em;
  font-size: 110%;
  font-weight: bold; }
  


div.section, div.back-section {
  margin-top: 1em; margin-bottom: 0.5em }

div.section h1, h2, h3, h4, h5, h6 {
    font-size: 1.3em;
    font-weight: bold;
    color: #6d220c;
}
    

div.panel { background-color: white;
  font-size: 90%;
  border: thin solid black;
  padding-left: 0.5em; padding-right: 0.5em;
  padding-top: 0.5em; padding-bottom: 0.5em;
  margin-top: 2em; margin-bottom: 2em;}

div.panel img {
    max-width: 100%;
    min-width: 50%;
    margin-top: 2ex;
    margin-left: auto;
    margin-right: auto;
    display: block;
}
div.panel.h1, h2, h3, h4 {
    font-size: 1.1em;
}

div.blockquote { font-size: 90%;
  margin-left: 3em; margin-right: 3em;
  margin-top: 2em; margin-bottom: 2em }

div.caption {
  margin-top: 0.5em; margin-bottom: 0.5em }

div.speech {
  margin-left: 1em; margin-right: 1em;
  margin-top: 0.5em; margin-bottom: 0.5em }

div.verse-group {
  margin-left: 1em;
  margin-top: 0.5em; margin-bottom: 0.5em }

div.verse-group div.verse-group {
  margin-left: 1em;
  margin-top: 0em; margin-bottom: 0em }

div.note { margin-top: 0em; margin-left: 1em;
  font-size: 85% }

.ref-label { margin-top: 0em; vertical-align: top }

.ref-content { margin-top: 0em; padding-left: 0.25em }

h5.label { margin-top: 0em; margin-bottom: 0em }

p { margin-top: 0.5em; margin-bottom: 0em }

p.first { margin-top: 0em }

p.verse-line, p.citation { margin-top: 0em; margin-bottom: 0em; margin-left: 2em; text-indent: -2em; font-size: 90%}

p.address-line { margin-top: 0em; margin-bottom: 0em; margin-left: 2em }

ul, ol { margin-top: 0.5em }

li { margin-top: 0.5em; margin-bottom: 0em }
li > p { margin-top: 0.2em; margin-bottom: 0em  }

div.def-list { border-spacing: 0.25em }

div.def-list div.cell { vertical-align: top;
  border-bottom: thin solid black;
  padding-bottom: 0.5em }

div.def-list div.def-list-head {
  text-align: left }

/* text decoration */
.label { font-weight: bold; font-family: sans-serif; font-size: 80% }

.monospace {
	font-family: monospace;
	}

.overline{
	text-decoration: overline;
	}
 
/*a       { text-decoration: none }
a:hover { text-decoration: underline }*/

.orcid {
     font-weight: bold;
    font-size: 0.9em;
}
.orcid a {
    font-weight: bold;
    text-decoration: none;
   background: none;
}
.orcid a:active {
    font-weight: bold;
   text-decoration: none;
 }
  .orcid a:visited {
    font-weight: bold;
    text-decoration: none;
 }
 .orcid a:hover {
    font-weight: bold;
    text-decoration: none;
     background: none;
 }

 
a,
a:active {
    text-decoration: none;
    color: #6b2222;
    background: #e3e3e5;
}
a:visited {
    color: #904737;
    text-decoration: underline;
}
a:hover {
    color: #000000;
    text-decoration: none;
    background: #b9b9c2;
	
}

/*a {
    padding: 1px 2px 3px 2px;
    color: #000;
    text-decoration: none;
    background-color: #E7FBF4;
}
a:hover {
    background-color: #E7FBF4;
    background-color: #E7FBF4;
    text-decoration: underline;
}*/

a.xref-bibr {
    padding: 1px 2px 3px 2px;
    color: #000;
    text-decoration: none;
    background-color: #d2d2d4;
}
a:hover.xref-bibr {
    background-color: #d2d2d4;
    text-decoration: none;
    background: #d2d2d4;
}




/* ---------------- End ------------------------------ */

